BDBM50079375 CHEMBL3417008::US9663465, 20

SMILES COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1

InChI Key InChIKey=FQTXEUSQQPBRJW-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50079375   

TargetAcetylcholinesterase(Human)
Cermn

Curated by ChEMBL
LigandPNGBDBM50079375(CHEMBL3417008 | US9663465, 20)
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of human erythrocyte AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate by Ellman' methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Cermn

Curated by ChEMBL
LigandPNGBDBM50079375(CHEMBL3417008 | US9663465, 20)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of equine serum BuChE pre-incubated for 5 mins before butyrylthiocholine iodide substrate by Ellman' methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Cermn

Curated by ChEMBL
LigandPNGBDBM50079375(CHEMBL3417008 | US9663465, 20)
Affinity DataIC50: 2.72E+3nMAssay Description:Acetylcholinesterase extracted from human erythrocytes (buffered aqueous solution, ≧500 units/mg, Sigma Aldrich) is diluted in a 20 mM HEPES bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 4(Human)
Universite De Caen

US Patent
LigandPNGBDBM50079375(CHEMBL3417008 | US9663465, 20)
Affinity DataKi:  0.900nMAssay Description:Prior to these competition studies, a series of saturation curves were performed in order to check whether the pharmacological parameters Kd, Bmax an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 4(Guinea pig)
Cermn

Curated by ChEMBL
LigandPNGBDBM50079375(CHEMBL3417008 | US9663465, 20)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed