BDBM50079170 1-(1-Benzyl-piperidin-4-yl)-3-phenyl-urea::CHEMBL91621::US11116757, No. B20

SMILES O=C(NC1CCN(Cc2ccccc2)CC1)Nc1ccccc1

InChI Key InChIKey=FBRUCPZAISLOOV-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50079170   

TargetDCN1-like protein 1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50079170(1-(1-Benzyl-piperidin-4-yl)-3-phenyl-urea | CHEMBL...)
Affinity DataIC50: 6.70E+4nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Human)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50079170(1-(1-Benzyl-piperidin-4-yl)-3-phenyl-urea | CHEMBL...)
Affinity DataIC50: 4.10nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079170(1-(1-Benzyl-piperidin-4-yl)-3-phenyl-urea | CHEMBL...)
Affinity DataKi:  86nMAssay Description:Affinity to displace [3H]spiperone from cloned human Dopamine receptor D2 stably expressed in CHO cell linesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079170(1-(1-Benzyl-piperidin-4-yl)-3-phenyl-urea | CHEMBL...)
Affinity DataKi:  390nMAssay Description:Affinity to displace [3H]spiperone from cloned human Dopamine receptor D4 stably expressed in HEK393 cell linesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079170(1-(1-Benzyl-piperidin-4-yl)-3-phenyl-urea | CHEMBL...)
Affinity DataKi:  700nMAssay Description:Affinity to displace [3H]spiperone from cloned human Dopamine receptor D3 (hD3) stably expressed in HEK393 cell linesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed