BDBM50078065 CHEMBL70609::Methanesulfonic acid 11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-yl ester

SMILES CN1CCN(CC1)C1=Nc2cc(OS(C)(=O)=O)ccc2Nc2ccccc12

InChI Key InChIKey=CCMSWCPOSSFEQM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50078065   

TargetMuscarinic acetylcholine receptor M1(Human)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50078065(Methanesulfonic acid 11-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of binding of 1.0 nM [3H]pirenzepine to cloned human Muscarinic acetylcholine receptor M1 expressed in membranes from CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50078065(Methanesulfonic acid 11-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50: 7.40E+3nMAssay Description:Binding affinity towards 5-HT2C receptor from rat using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50078065(Methanesulfonic acid 11-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50: 2.20E+4nMAssay Description:Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50078065(Methanesulfonic acid 11-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50: 3.30E+4nMAssay Description:Binding affinity towards Dopamine receptor D2 of rat corpus striatum using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of GöTeborg

Curated by ChEMBL
LigandPNGBDBM50078065(Methanesulfonic acid 11-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50: 4.90E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor from rat frontal cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed