BDBM50077888 CHEMBL3417060::US9611229, 18

SMILES Fc1cccc(Cn2cc(NCCN3CCCCC3)nn2)c1

InChI Key InChIKey=IASGPWUGLFJLOL-UHFFFAOYSA-N

Data  2 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50077888   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Esteve

Curated by ChEMBL

LigandBDBM50077888(CHEMBL3417060 | US9611229, 18)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/26/2016
Entry Details Article
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TargetSigma non-opioid intracellular receptor 1(Human)
Esteve

Curated by ChEMBL

LigandBDBM50077888(CHEMBL3417060 | US9611229, 18)Copy SMILESCopy InChI

Affinity DataKi:  35nMAssay Description:Displacement of [3H](+)-pentazocine from human sigma 1 receptor transfected in HEK293 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/26/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetSigma non-opioid intracellular receptor 1(Mouse)
Laboratorios Del Dr. Esteve

US Patent

LigandBDBM50077888(CHEMBL3417060 | US9611229, 18)Copy SMILESCopy InChI

Affinity DataKi:  35.4nMAssay Description:Brain membrane preparation and binding assays for the 61-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y. For...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/29/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL