BDBM50077238 CHEMBL280757::N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide

SMILES Fc1ccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)cc1Br

InChI Key InChIKey=YXFCBQUDPXMRJR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50077238   

TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077238(N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-y...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077238(N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-y...)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077238(N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-y...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of heregulin-stimulated autophosphorylation of ERBB2 receptor kinase in MDA-MB-453 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077238(N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-y...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of autophosphorylation of ERBB2 receptor kinase in MDA-MB 453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077238(N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-y...)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077238(N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-y...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed