BDBM50077236 CHEMBL54088::N-(4-m-Tolylamino-pyrido[3,4-d]pyrimidin-6-yl)-acrylamide

SMILES Cc1cccc(Nc2ncnc3cnc(NC(=O)C=C)cc23)c1

InChI Key InChIKey=ZQAIYVKPDMZOOX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50077236   

TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077236(N-(4-m-Tolylamino-pyrido[3,4-d]pyrimidin-6-yl)-acr...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077236(N-(4-m-Tolylamino-pyrido[3,4-d]pyrimidin-6-yl)-acr...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of heregulin-stimulated autophosphorylation of erbB2 in MDA-MB-453 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077236(N-(4-m-Tolylamino-pyrido[3,4-d]pyrimidin-6-yl)-acr...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed