BDBM50077151 (R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfonylamino]-3-methyl-butyric acid::CHEMBL49413

SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O

InChI Key InChIKey=ZDCLAWKUXDCGDW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50077151   

TargetMatrix metalloproteinase-9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50: 4.40nMAssay Description:Inhibitory activity against Matrix metalloprotease-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50: 4.80nMAssay Description:Inhibitory activity against Matrix metalloprotease-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of MMP-9 (unknown origin) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 60 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MMP2 (unknown origin) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 60 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed