BDBM50076744 CHEMBL3416733

SMILES CC(C)C[C@H](CP(=O)([C@H](CCc1ccccc1)N)O)C(=O)N[C@@H](Cc2c[nH]c3c2cccc3)C(=O)N

InChI Key InChIKey=QKFOTLXPIIESQI-UHFFFAOYSA-N

Data  23 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50076744   

TargetEndoplasmic reticulum aminopeptidase 2(Human)
Institut Pasteur De Lille

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 7.55E+5nMAssay Description:Inhibition of human ERAP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Institut Pasteur De Lille

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ERAP2 using R-AMC as substrate incubated for 5 to 10 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human ERAP1 using L-AMC as substrate incubated for 5 to 10 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Institut Pasteur De Lille

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of ERAP2 (unknown origin) using R-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Institut Pasteur De Lille

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of ERAP2 (unknown origin) using R-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 190nMAssay Description:Inhibition of ERAP1 (unknown origin) using L-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 186nMAssay Description:Inhibition of ERAP1 (unknown origin) using L-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAminopeptidase N(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of APN (unknown origin) using A-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of APN (unknown origin) using A-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 1nMAssay Description:Inhibition of APN (unknown origin) using Ala-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 52nMAssay Description:Inhibition of wild type ERAP1 (unknown origin) using L-Rho-Succ-FKARKF as substrate preincubated for 15 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human ERAP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Institut Pasteur De Lille

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant ERAP2 expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-arginyl-7-amido-4-methyl coumarin as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant ERAP1 using L-leucine 7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence microplate reader met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant ERAP1 using L-leucine 7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence microplate reader met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Institut Pasteur De Lille

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 80nMAssay Description:Inhibition of ERAP2 (unknown origin) expressed in Hi5 cells by in vitro fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 48nMAssay Description:Inhibition of ERAP1 (unknown origin) expressed in Hi5 cells by in vitro fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeucyl-cystinyl aminopeptidase(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 57nMAssay Description:Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Institut Pasteur De Lille

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus infected insect cells using L-arginine-7-amido-4-methylcoumarine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Institut Pasteur De Lille

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ERAP2 using R-AMC as substrate measured for 15 to 30 mins by microplate fluorescence reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant ERAP1 expressed in baculovirus infected Sf9 cells using L-leucine-7-amido-4-methyl coumarin as substrate after 5 to 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeucyl-cystinyl aminopeptidase(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant IRAP expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-leucine-7-amido-4-methyl coumarin as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed