BDBM50076691 7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one::CHEMBL7289

SMILES CC1(C)CCc2cc3c(cc(=O)oc3cc2N1)C(F)(F)F

InChI Key InChIKey=XCAOBUOTWGIJFB-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50076691   

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076691(7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 1nMAssay Description:In vitro agonistic activity against human androgen receptor using cotransfection assay in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076691(7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro antagonistic activity against human glucocorticoid receptor (hGR); not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076691(7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro antagonistic activity against human mineralocorticoid receptor (hMR); not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076691(7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 570nMAssay Description:In vitro antagonistic activity against human progesterone receptor (hPR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076691(7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro antagonistic activity against human estrogen receptor (hER); not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076691(7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-...)
Affinity DataEC50:  9nMAssay Description:In vitro agonistic activity against human androgen receptor using cotransfection assay in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076691(7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 10nMAssay Description:In vitro antagonistic activity against human androgen receptor using cotransfection assay in CV-1 cells; Not active.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed