BDBM50076666 CHEMBL175153::N-Hydroxy-N-{3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-1-methyl-prop-2-ynyl}-acetamide

SMILES COc1ccc(cc1)-n1nc(cc1-c1ccc(C)cc1)C#CC(C)N(O)C(C)=O

InChI Key InChIKey=KNZSXUMSPZBUEG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50076666   

TargetProstaglandin G/H synthase 1(Sheep)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076666(N-Hydroxy-N-{3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-...)
Affinity DataIC50: 310nMAssay Description:Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076666(N-Hydroxy-N-{3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-...)
Affinity DataIC50: 80nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076666(N-Hydroxy-N-{3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-...)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076666(N-Hydroxy-N-{3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076666(N-Hydroxy-N-{3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-...)
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed