BDBM50076653 CHEMBL366595::N-{1-isopropyl-3-[1-(4-methoxyphenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]prop-2-ynyl}-N-hydroxyurea

SMILES COc1ccc(cc1)-n1nc(cc1-c1ccc(C)cc1)C#CC(C(C)C)N(O)C(N)=O

InChI Key InChIKey=JLMBKHWPBHBNOK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50076653   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076653(N-{1-isopropyl-3-[1-(4-methoxyphenyl)-5-(4-methylp...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076653(N-{1-isopropyl-3-[1-(4-methoxyphenyl)-5-(4-methylp...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076653(N-{1-isopropyl-3-[1-(4-methoxyphenyl)-5-(4-methylp...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076653(N-{1-isopropyl-3-[1-(4-methoxyphenyl)-5-(4-methylp...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed