BDBM50076641 CHEMBL176844::N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-1-methyl-prop-2-ynyl}-N-hydroxy-isobutyramide

SMILES CCc1ccc(cc1)-c1cc(nn1-c1ccc(OC)cc1)C#CC(C)N(O)C(=O)C(C)C

InChI Key InChIKey=FUXVQILQPYRMIO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50076641   

TargetProstaglandin G/H synthase 1(Sheep)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076641(N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-p...)
Affinity DataIC50: 590nMAssay Description:Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076641(N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-p...)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076641(N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-p...)
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed