BDBM50076639 CHEMBL367010::N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-1-methyl-prop-2-ynyl}-N-hydroxy-acetamide

SMILES CCc1ccc(cc1)-c1cc(nn1-c1ccc(OC)cc1)C#CC(C)N(O)C(C)=O

InChI Key InChIKey=XENSRURITZPCDA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50076639   

TargetProstaglandin G/H synthase 1(Sheep)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076639(N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-p...)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076639(N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-p...)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076639(N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-p...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076639(N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-p...)
Affinity DataIC50: 60nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076639(N-{3-[5-(4-Ethyl-phenyl)-1-(4-methoxy-phenyl)-1H-p...)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed