BDBM50076311 5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one::CHEMBL34824

SMILES CC1C(=O)C(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cccc(F)c4)c3c12

InChI Key InChIKey=RUEYZSNXUIKMJQ-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50076311   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076311(5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-tri...)
Affinity DataEC50:  25nMAssay Description:Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076311(5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-tri...)
Affinity DataEC50:  8.70nMAssay Description:Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076311(5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-tri...)
Affinity DataKi:  3.5nMAssay Description:Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076311(5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-tri...)
Affinity DataKi:  560nMAssay Description:Binding affinity against baculovirus expressed human androgen receptor (hAR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076311(5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-tri...)
Affinity DataKi:  4.73E+3nMAssay Description:Binding affinity against baculovirus expressed human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed