BDBM50076300 2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one::CHEMBL32603

SMILES CC1C(=O)C(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4ccccc4)c3c12

InChI Key InChIKey=OCLPHOSZZDWUFZ-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50076300   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076300(2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-1,2,...)
Affinity DataEC50:  17nMAssay Description:Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076300(2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-1,2,...)
Affinity DataEC50:  18nMAssay Description:Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076300(2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-1,2,...)
Affinity DataKi:  4.90nMAssay Description:Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076300(2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-1,2,...)
Affinity DataKi:  680nMAssay Description:Binding affinity against baculovirus expressed human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076300(2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-1,2,...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity against baculovirus expressed human androgen receptor (hAR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed