BDBM50076132 (S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-pentanoic acid::CHEMBL26720

SMILES CC(C)C[C@H](NC(=O)c1cc(NCc2ccncc2)ccc1-c1ccccc1)C(O)=O

InChI Key InChIKey=FTCZIJXHWDHTQT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50076132   

LigandPNGBDBM50076132((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50076132((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)
Affinity DataIC50: 400nMAssay Description:In vitro inhibition of [3H]GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50076132((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro inhibition of [3H]FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed