BDBM50075782 4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]-benzoic acid::CHEMBL423781

SMILES OC(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1

InChI Key InChIKey=IOTPUQIURNWCBL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075782   

TargetMitogen-activated protein kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075782(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50: 90nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075782(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the human glucagon receptor (GGR) expressed on CHO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075782(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50: 90nMAssay Description:Inhibitory activity against Mitogen-activated protein kinase 14, p38-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075782(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article