BDBM50075769 4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine::CHEMBL348401

SMILES Fc1ccc(cc1)-c1cc([nH]c1-c1ccncc1)C1CCCCC1

InChI Key InChIKey=KVOWJSITTRQRSW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50075769   

TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075769(4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075769(4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl...)
Affinity DataIC50: 490nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the human glucagon receptor (GGR) expressed on CHO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075769(4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl...)
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075769(4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the murine glucagon receptor (GGR) expressed on CH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075769(4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl...)
Affinity DataIC50: 90nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075769(4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article