BDBM50075755 4-[5-(4-Chloro-phenyl)-3-(2-isopropoxy-phenyl)-1H-pyrrol-2-yl]-pyridine::CHEMBL160561

SMILES CC(C)Oc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1

InChI Key InChIKey=MXSHQUWVYUZAOW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50075755   

TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075755(4-[5-(4-Chloro-phenyl)-3-(2-isopropoxy-phenyl)-1H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075755(4-[5-(4-Chloro-phenyl)-3-(2-isopropoxy-phenyl)-1H-...)
Affinity DataIC50: 910nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the human glucagon receptor (GGR) expressed on CHO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075755(4-[5-(4-Chloro-phenyl)-3-(2-isopropoxy-phenyl)-1H-...)
Affinity DataIC50: 5.54E+3nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075755(4-[5-(4-Chloro-phenyl)-3-(2-isopropoxy-phenyl)-1H-...)
Affinity DataIC50: 700nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the murine glucagon receptor (GGR) expressed on CH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075755(4-[5-(4-Chloro-phenyl)-3-(2-isopropoxy-phenyl)-1H-...)
Affinity DataIC50: 30nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed