BDBM50074742 CHEMBL7866::[3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-quinolin-1-yl]-acetic acid methyl ester

SMILES COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12

InChI Key InChIKey=CXCSYLLGUQWHHQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50074742   

TargetProtein kinase C alpha type(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50074742([3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50074742([3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-...)
Affinity DataIC50: 64nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50074742([3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of v-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50074742([3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor-dependent phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50074742([3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p60 c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50074742([3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of Epidermal growth factor receptor-dependent phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Mouse)
Novartis

Curated by ChEMBL
LigandPNGBDBM50074742([3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-...)
Affinity DataIC50: 9.55E+3nMAssay Description:Inhibition of EGF-dependent mouse keratinocyte MK cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed