BDBM50073772 CHEMBL173237::CHEMBL534909::N*2*-(2-Amino-ethyl)-9-ethyl-N*6*-(3-trifluoromethyl-phenyl)-9H-purine-2,6-diamine; hydrochloride

SMILES CCn1cnc2c(Nc3cccc(c3)C(F)(F)F)nc(NCCN)nc12

InChI Key InChIKey=DIEYJCDILBBDAH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50073772   

TargetCyclin-dependent kinase 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073772(CHEMBL173237 | N*2*-(2-Amino-ethyl)-9-ethyl-N*6*-(...)
Affinity DataIC50: 700nMAssay Description:Inhibition of Cyclin-dependent kinase 1, CDK1-related human bladder carcinoma (T24) cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073772(CHEMBL173237 | N*2*-(2-Amino-ethyl)-9-ethyl-N*6*-(...)
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073772(CHEMBL173237 | N*2*-(2-Amino-ethyl)-9-ethyl-N*6*-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibit of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073772(CHEMBL173237 | N*2*-(2-Amino-ethyl)-9-ethyl-N*6*-(...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073772(CHEMBL173237 | N*2*-(2-Amino-ethyl)-9-ethyl-N*6*-(...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of Protein kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed