BDBM50073438 CHEMBL278165::[5-Bromo-2-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-methanol

SMILES CN(C)Cc1ccccc1Sc1ccc(Br)cc1CO

InChI Key InChIKey=CHLYWPGOYPDIPF-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50073438   

TargetSodium-dependent serotonin transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073438([5-Bromo-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  0.520nMAssay Description:In vitro binding affinity against Serotonin transporter (SERT) from LLC-PK1 cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50073438([5-Bromo-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  1.92nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50073438([5-Bromo-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of [3H]nisoxetine binding to norepinephrine transporter (NET) of rat cortical homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073438([5-Bromo-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  35nMAssay Description:In vitro binding affinity against monoamine transporter NET (norepinephrine transporter) in LLC-PK1 cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50073438([5-Bromo-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  950nMAssay Description:Inhibition of [3H]-GBR-12,935 binding to dopamine transporter (DAT) of rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073438([5-Bromo-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine transporter in LLC-PK1 cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed