BDBM50073429 CHEMBL82032::CHEMBL84575::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O

InChI Key InChIKey=PIIUKKBKYNGKMK-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50073429   

TargetSerine protease 1(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 101nMAssay Description:In vitro inhibitory activity was evaluated against human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Rat)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibitory activity was evaluated against thrombolytic enzyme plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 40nMAssay Description:In vitro inhibitory activity was evaluated against Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 0.710nMAssay Description:In vitro inhibitory activity against human enzyme thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 21nMAssay Description:In vitro inhibitory activity against human prothrombinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 75nMAssay Description:In vitro evaluation of inhibition of cleavage of the chromogenic substrate by human enzyme trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibitory activity against human enzyme plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 0.710nMAssay Description:The compound was tested in vitro for inhibitory activity against Coagulation factor IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSerine protease 1(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 152nMAssay Description:The compound was tested in vitro for inhibitory activity against human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCoagulation factor X(Human)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50073429(CHEMBL84575 | CHEMBL82032 | N-((S)-1-Carbamimidoyl...)
Affinity DataIC50: 23nMAssay Description:The compound was tested in vitro for inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article