BDBM50072664 CHEMBL3410036

SMILES Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4)cc3)c12

InChI Key InChIKey=WQAGVQVBDHOHRD-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50072664   

TargetLIM domain kinase 1(Rat)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 470nMAssay Description:Inhibition of Limk1 in rat A7r5 cells assessed as reduction in cofilin phosphorylation by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 43nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 6.57E+3nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 5.54E+3nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 372nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 741nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 550nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 468nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 43nMAssay Description:Inhibition of LIMK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50072664(CHEMBL3410036)
Affinity DataIC50: 24nMAssay Description:Inhibition of LIMK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed