BDBM50072244 (Z)-4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid::4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid (0.1H2O)::CHEMBL23923

SMILES OC(=O)C(=O)CC(=O)c1ccc(F)c(F)c1

InChI Key InChIKey=POPZWTVHXZVCHP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50072244   

TargetKynurenine 3-monooxygenase(Rat)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072244(4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50: 120nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072244(4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50: 1.20E+3nMAssay Description:Compound was evaluated for the inhibition of rat brain KYN 3-OHaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072244(4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50: 440nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed