BDBM50071700 CHEMBL81889::Cyanoguanidine derivative

SMILES Clc1ccc2c(-[#16]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](-[#7]-[#6]-c2ccncc2)=[#7]C#N)c1

InChI Key InChIKey=IGWWHHJGUAVAGC-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50071700   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Schering-Plough Research Institute

Curated by ChEMBL

LigandBDBM50071700(Cyanoguanidine derivative | CHEMBL81889)Copy SMILESCopy InChI

Affinity DataIC50: 43nMAssay Description:In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Schering-Plough Research Institute

Curated by ChEMBL

LigandBDBM50071700(Cyanoguanidine derivative | CHEMBL81889)Copy SMILESCopy InChI

Affinity DataIC50: 1.70E+3nMAssay Description:In vitro inhibition of Ras processing in COS cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL