BDBM50071264 (9S,10R,13S)-10-Isobutyl-11-oxo-2-oxa-12-aza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-triene-9,13-dicarboxylic acid 9-hydroxyamide 13-methylamide::CHEMBL293003

SMILES CNC(=O)[C@@H]1Cc2ccc(OCCCCCC[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO)cc2

InChI Key InChIKey=VCJOCQOXJUMEBE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50071264   

TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50071264((9S,10R,13S)-10-Isobutyl-11-oxo-2-oxa-12-aza-bicyc...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of fibroblast collagenase (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50071264((9S,10R,13S)-10-Isobutyl-11-oxo-2-oxa-12-aza-bicyc...)
Affinity DataIC50: 12nMAssay Description:Inhibition of fibroblast stromelysin (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50071264((9S,10R,13S)-10-Isobutyl-11-oxo-2-oxa-12-aza-bicyc...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of fibroblast gelatinase A (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50071264((9S,10R,13S)-10-Isobutyl-11-oxo-2-oxa-12-aza-bicyc...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of fibroblast matrilysin (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed