BDBM50071127 (E)-7-{4-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-phenyl}-7-pyridin-3-yl-hept-6-enoic acid::CHEMBL299467

SMILES OC(=O)CCCC\C=C(/c1ccc(cc1)-c1nc(co1)C(=O)NCCCCC1CCCCC1)c1cccnc1

InChI Key InChIKey=ZNRZNAHHOIANAO-UHFFFAOYSA-N

Data  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50071127   

TargetThromboxane-A synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071127((E)-7-{4-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataIC50: 550nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071127((E)-7-{4-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataKd:  9.90nMAssay Description:In vitro thromboxane receptor antagonism was determined using a human platelet binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071127((E)-7-{4-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataIC50: 55nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071127((E)-7-{4-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataKd:  9.90nMAssay Description:Compound was tested in vitro for antagonistic activity against thromboxane receptor. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071127((E)-7-{4-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataIC50: 550nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071127((E)-7-{4-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataKd:  9.90nMAssay Description:In vitro thromboxane receptor antagonism was determined using a human platelet binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed