BDBM50070566 5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl)-2-methoxy-6-methylamino-nicotinamide::CHEMBL40497

SMILES CCN1CCN(C)C[C@@H](C1)NC(=O)c1cc(Br)c(NC)nc1OC

InChI Key InChIKey=FKDXBULKZKICQO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50070566   

TargetD(2) dopamine receptor(Rat)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50070566(5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Affinity DataIC50: 81nMAssay Description:Inhibition of [3H]- spiperone binding to rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50070566(5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Affinity DataIC50: 1.28nMAssay Description:Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50070566(5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration of compound required to inhibit the binding of radioligand [3H]GR-113808 to 5-hydroxytryptamine 4 receptor in guinea-pig striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50070566(5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Affinity DataIC50: 122nMAssay Description:Inhibition of the binding of radioligand [3H]spiperone to dopamine receptor D2 in rat brain synaptic membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50070566(5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Affinity DataIC50: 14.3nMAssay Description:Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50070566(5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [3H]GR-65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed