BDBM50069571 3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5-ylmethyl-5,6-dimethoxy-1H-indole-2-carboxylic acid::CHEMBL68557

SMILES COc1cc2c(c(C(O)=O)n(Cc3ccc4nsnc4c3)c2cc1OC)-c1ccc2OCOc2c1

InChI Key InChIKey=WBPPFODALXOLOK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50069571   

TargetEndothelin-1 receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50069571(3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5...)
Affinity DataIC50: 33nMAssay Description:Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50069571(3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of [125I]ET1 binding to porcine kidney inner medulla membrane Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50069571(3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5...)
Affinity DataIC50: 33nMAssay Description:Potency at Endothelin A receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed