BDBM50068700 Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide::CHEMBL310427

SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C

InChI Key InChIKey=SLBYWDJLJLBXGV-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50068700   

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50068700(Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataIC50: 8.30nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50068700(Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataIC50: 5.50E+4nMAssay Description:Binding affinity against human ETB receptor in transfected COS 7 cell membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068700(Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataKi:  90nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068700(Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataKi: >2.00E+5nMAssay Description:Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed