BDBM50068459 1-[2-(4-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)-piperazine::CHEMBL144490

SMILES COc1ccc(CCN2CCN(CCCc3ccccc3)CC2)cc1

InChI Key InChIKey=PPMWKOUCHYHRKC-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50068459   

TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50068459(1-[2-(4-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity was tested against sigma-1 receptor in guinea brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri

Curated by ChEMBL
LigandPNGBDBM50068459(1-[2-(4-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Mouse)
University of Missouri

Curated by ChEMBL
LigandPNGBDBM50068459(1-[2-(4-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  1.47E+3nMAssay Description:Displacement of [3H]RTI-121 from mouse DAT in striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Mouse)
University of Missouri

Curated by ChEMBL
LigandPNGBDBM50068459(1-[2-(4-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  1.73E+3nMAssay Description:Displacement of [3H]paroxetine from mouse SERT in whole brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed