BDBM50068451 1,4-Bis-[2-(4-methoxy-phenyl)-ethyl]-piperazine::CHEMBL146411

SMILES COc1ccc(CCN2CCN(CCc3ccc(OC)cc3)CC2)cc1

InChI Key InChIKey=XKAGEHNVPVOYAQ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50068451   

TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50068451(1,4-Bis-[2-(4-methoxy-phenyl)-ethyl]-piperazine | ...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity was tested against sigma-1 receptor in guinea brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50068451(1,4-Bis-[2-(4-methoxy-phenyl)-ethyl]-piperazine | ...)
Affinity DataKi:  410nMAssay Description:Inhibition of VMAT2 in rat striatal homogenate assessed as reduction in [3H]DA uptake after 8 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50068451(1,4-Bis-[2-(4-methoxy-phenyl)-ethyl]-piperazine | ...)
Affinity DataKi:  6.63E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat whole brain homogenate (excluding cerebellum) after 30 mins by liquid scintillation spectrometric anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed