BDBM50068000 CHEMBL3305167

SMILES COc1ccc2c(n1)c(c(cn2)F)C[C@@H](C34CCC(CC3)(CO4)NCc5ccc6c(n5)NC(=O)CO6)O

InChI Key InChIKey=JWCUKLIKGBNEKA-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50068000   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068000(CHEMBL3305167)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human ERG by MK499 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068000(CHEMBL3305167)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by Patch express assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068000(CHEMBL3305167)
Affinity DataIC50: 26nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068000(CHEMBL3305167)
Affinity DataIC50: 18nMAssay Description:Inhibition of human ERG expressed in CHO cells by Patch express assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068000(CHEMBL3305167)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human ERG assessed as reduction in MK499 competitive bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068000(CHEMBL3305167)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch express method based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068000(CHEMBL3305167)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed