BDBM50067895 CHEMBL140780::Tolyl boronic acid::p-tolylboronic acid

SMILES Cc1ccc(cc1)B(O)O

InChI Key InChIKey=BIWQNIMLAISTBV-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50067895   

TargetEndothelial lipase(Human)
Tufts University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50067895(Tolyl boronic acid | p-tolylboronic acid | CHEMBL1...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human endothelial lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLipoprotein lipase(Human)
Tufts University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50067895(Tolyl boronic acid | p-tolylboronic acid | CHEMBL1...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLipoprotein lipase(Human)
Tufts University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50067895(Tolyl boronic acid | p-tolylboronic acid | CHEMBL1...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Tufts University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50067895(Tolyl boronic acid | p-tolylboronic acid | CHEMBL1...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human endothelial lipase overexpressed in HUVEC cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University Medical School

Curated by ChEMBL
LigandPNGBDBM50067895(Tolyl boronic acid | p-tolylboronic acid | CHEMBL1...)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibitory activity against Escherichia coli AmpC beta-lactamase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase(Yeast)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50067895(Tolyl boronic acid | p-tolylboronic acid | CHEMBL1...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50067895(Tolyl boronic acid | p-tolylboronic acid | CHEMBL1...)
Affinity DataKi:  1.08E+4nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50067895(Tolyl boronic acid | p-tolylboronic acid | CHEMBL1...)
Affinity DataKi:  2.78E+5nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed