BDBM50067207 CHEMBL3304438

SMILES CC(C)c1cc(on1)CNC(=O)c2ccc(c(c2)OC3CCN(CC3)C)OC

InChI Key InChIKey=WBLVOWHFRUAMCP-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50067207   

TargetHigh affinity choline transporter 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 270nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 100 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity choline transporter 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 90nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1A2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 72nMAssay Description:Inhibition of [3H]choline uptake at human choline transporter expressed in HEK293 cells preincubated for 15 mins followed by [3H]choline addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C9(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50067207(CHEMBL3304438)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed