BDBM50067044 (1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-3-one::(1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one::1,5-Bis(4-hydroxyphenyl)penta-1,4-dien-3-one::1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-3-one::CHEMBL129134

SMILES Oc1ccc(\C=C\C(=O)\C=C\c2ccc(O)cc2)cc1

InChI Key InChIKey=FTEGUKWEUQPKIS-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50067044   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Wenzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 4.42E+3nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol after 60 to 90 mins by radiom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Wenzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 986nMAssay Description:Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Wenzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 832nMAssay Description:Inhibition of human 11beta-HSD1 transfected in CHOP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 7.91E+4nMAssay Description:Inhibition of tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against HIV-1 Integrase (HIV-1-IN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTissue factor(Human)TBA
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article