BDBM50067030 (1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydroxy-hepta-1,4,6-trien-3-one::(1E,4Z,6E)-1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one::1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydroxy-hepta-1,4,6-trien-3-one::1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one::CHEMBL129964

SMILES Oc1ccc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(O)c2)cc1O

InChI Key InChIKey=OJFGQVZAISEIPG-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50067030   

TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50067030(1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of GST-p300 HAT assessed as histone acetylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50067030(1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-...)
Affinity DataIC50: 700nMAssay Description:Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50067030(1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-...)
Affinity DataIC50: 708nMAssay Description:Inhibitory activity against HIV-1 Integrase (HIV-1-IN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50067030(1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-...)
Affinity DataEC50:  1.25E+4nMAssay Description:Binding affinity to GST-tagged PKCdelta expressed in Escherichia coli BL21(DE3) by fluorescence quenchingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50067030(1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-...)
Affinity DataEC50:  1.11E+4nMAssay Description:Binding affinity to GST-tagged PKCepsilon expressed in Escherichia coli BL21(DE3) by fluorescence quenchingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50067030(1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-...)
Affinity DataEC50:  6.57E+3nMAssay Description:Binding affinity to GST-tagged PKCtheta expressed in Escherichia coli BL21(DE3) by fluorescence quenchingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Yamagata University

Curated by ChEMBL
LigandPNGBDBM50067030(1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-...)
Affinity DataIC50: 2.20E+6nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed