BDBM50066871 CHEMBL3401671

SMILES CS(=O)(=O)c1ccc(cc1)N1CCN(CC1)c1cccc(n1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50066871   

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50066871(CHEMBL3401671)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 using microsomal fraction and NADPH assessed as conversion of cortisone to cortisol by biochemical enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50066871(CHEMBL3401671)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50066871(CHEMBL3401671)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of mouse 11beta-HSD1 using microsomal fraction and NADPH assessed as conversion of cortisone to cortisol by biochemical enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50066871(CHEMBL3401671)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human 11beta-HSD1 using microsomal fraction and NADPH assessed as conversion of cortisone to cortisol by biochemical enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed