BDBM50066526 3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6-yl)-benzonitrile::3-fluoro-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)benzonitrile::CHEMBL117465

SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N

InChI Key InChIKey=POQODJWQWWICOY-UHFFFAOYSA-N

Data  3 KI  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50066526   

TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Cross-reactivity as binding to human mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataEC50:  2.20E+3nMAssay Description:Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataIC50: 37nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataIC50: 210nMAssay Description:Cross-reactivity as binding to human androgen receptor (hAR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataIC50: 37nMAssay Description:Binding affinity against progesterone receptor using human T47D breast carcinoma cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataIC50: 30nMAssay Description:In vitro antagonist activity against human progesterone receptor isoform B(hPR-B) in mammalian(CV-1) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity against human progesterone receptor (hPR) expressed in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataKi:  10nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataKi:  10nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed