BDBM50066523 2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-quinoline::2,2,4-trimethyl-6-(3-nitrophenyl)-1,2-dihydroquinoline::CHEMBL93027

SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cccc(c1)[N+]([O-])=O

InChI Key InChIKey=RPMPNSIAJLJJTG-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50066523   

TargetProgesterone receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataIC50: 41nMAssay Description:Inhibitory concentration against progesterone stimulated alkaline phosphatase activity in T47D human breast carcinoma cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataIC50: 41nMAssay Description:Inhibition of 3 nM [3H]R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataIC50: 42nMAssay Description:Inhibitory concentration against progesterone induced PRE-luciferase activity in CV-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataIC50: 42nMAssay Description:In vitro antagonist activity against human progesterone receptor isoform B(hPR-B) in mammalian(CV-1) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataKi:  20nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataKi:  20nMAssay Description:Binding affinity towards progesterone receptor was measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed