BDBM50065454 CHEBI:63453::CHEMBL3348846

SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1

InChI Key InChIKey=VRQMAABPASPXMW-UHFFFAOYSA-N

Data  85 IC50  3 Kd  2 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 90 hits for monomerid = 50065454   

TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human FGFR1 (459 to 765 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataKoff:  5.10E+4s-1Assay Description:Inhibition of wild-type FGFR4 C477A mutant (unknown origin) assessed as ratio of Kinact to KiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataKoff:  5.10E+6s-1Assay Description:Inhibition of wild-type FGFR4 (unknown origin) assessed as ratio of Kinact to KiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 519nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 348nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human VEGFR2 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 165nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 46nMAssay Description:Inhibition of human FGFR4 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 24nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human FGFR2 (458 to 768 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human FGFR3 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human VEGFR2 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human FGFR3 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 24nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FGFR2 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 165nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to FGFR1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 259nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Lanzhou University Second Hospital

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 369nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.950nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to FGFR3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to FGFR2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human KDR in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 165nMAssay Description:Inhibition of recombinant human FGFR4 in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human FGFR3 in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human FGFR2 in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human FGFR3 in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human FGFR2 in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 660nMAssay Description:Inhibition of human FGFR4 (445 to 753 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGFR3 (450 to 758 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FGFR3 in human RT112 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant human FGFR3 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 63nMAssay Description:Inhibition of FGFR1 in human NCI-H1581 cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human FGFR2 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human FGFR3 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
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