BDBM50065416 Benzyl-{1-[2-fluoro-3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-propyl]-piperidin-4-yl}-methyl-amine::CHEMBL416688

SMILES CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(cc23)-n2cnnc2)CC1

InChI Key InChIKey=ZHPQQZJJWUOHFA-UHFFFAOYSA-N

Data  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50065416   

Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065416(Benzyl-{1-[2-fluoro-3-(5-[1,2,4]triazol-4-yl-1H-in...)
Affinity DataEC50:  18nMAssay Description:Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065416(Benzyl-{1-[2-fluoro-3-(5-[1,2,4]triazol-4-yl-1H-in...)
Affinity DataIC50: 5.40nMAssay Description:Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065416(Benzyl-{1-[2-fluoro-3-(5-[1,2,4]triazol-4-yl-1H-in...)
Affinity DataEC50:  1.03E+5nMAssay Description:Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065416(Benzyl-{1-[2-fluoro-3-(5-[1,2,4]triazol-4-yl-1H-in...)
Affinity DataIC50: 5.40nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065416(Benzyl-{1-[2-fluoro-3-(5-[1,2,4]triazol-4-yl-1H-in...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065416(Benzyl-{1-[2-fluoro-3-(5-[1,2,4]triazol-4-yl-1H-in...)
Affinity DataEC50:  18nMAssay Description:Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed