BDBM50065275 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)indolin-2-one::3-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL89505

SMILES CC(C)(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(c1O)C(C)(C)C

InChI Key InChIKey=NUMNJHZZSGKINB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50065275   

LigandPNGBDBM50065275(3-(3,5-di-tert-butyl-4-hydroxybenzylidene)indolin-...)
Affinity DataIC50: 6.48E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065275(3-(3,5-di-tert-butyl-4-hydroxybenzylidene)indolin-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065275(3-(3,5-di-tert-butyl-4-hydroxybenzylidene)indolin-...)
Affinity DataIC50: 7.90E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065275(3-(3,5-di-tert-butyl-4-hydroxybenzylidene)indolin-...)
Affinity DataIC50: 4.95E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065275(3-(3,5-di-tert-butyl-4-hydroxybenzylidene)indolin-...)
Affinity DataIC50: 8.40E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065275(3-(3,5-di-tert-butyl-4-hydroxybenzylidene)indolin-...)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed