BDBM50065125 CHEMBL311230::N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)-3-chloro-phenyl]-2,4-dichloro-benzamide

SMILES Clc1ccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc34)c(Cl)c2)c(Cl)c1

InChI Key InChIKey=DPJXIUXSMVOLCY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50065125   

TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065125(N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepine-...)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065125(N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepine-...)
Affinity DataIC50: 640nMAssay Description:Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065125(N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepine-...)
Affinity DataIC50: 8.30nMAssay Description:Displacement of [3H]AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065125(N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepine-...)
Affinity DataIC50: 45nMAssay Description:Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed