BDBM50064341 (6S,7R,10S)-7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-6,10-dicarboxylic acid 6-hydroxyamide 10-methylamide::7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-6,10-dicarboxylic acid 6-hydroxyamide 10-methylamide (SE205)::CHEMBL45631

SMILES CNC(=O)[C@@H]1Cc2ccc(OCCC[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO)cc2

InChI Key InChIKey=USEJKZYMWYHGSP-UHFFFAOYSA-N

Data  6 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50064341   

TargetMatrilysin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataIC50: 3nMAssay Description:Inhibition of fibroblast matrilysin (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of fibroblast gelatinase A (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of fibroblast stromelysin (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataIC50: 3nMAssay Description:Inhibition of fibroblast collagenase (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of LPS-stimulated TNF-alpha release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of MMP-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  1.20nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of MMP-9 (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  32.7nMAssay Description:Inhibition of MMP-3 (Matrix metalloprotease-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  33nMAssay Description:Inhibition of human MMP-3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed