BDBM50064196 (2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amino)-ethyl]-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol::CHEMBL289948

SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN(C)c1ccccc1

InChI Key InChIKey=AKLDTUYECWDWIE-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50064196   

TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  5.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]pentazocine from guinea pig brain membrane sigma 1 receptor incubated for 150 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  29nMAssay Description:Displacement of [ 3H]-naloxone from rat brain membrane mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  29nMAssay Description:Displacement of [ 3H]-naloxone from rat brain membrane mu opioid receptor assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  124nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed