BDBM50064193 (2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol::CHEMBL41313

SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1

InChI Key InChIKey=PCYNRFPIZWFFRC-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50064193   

TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  114nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  7.80E+3nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards Dopamine receptor D2 in the rat striatal membranes using [3H]spiroperidolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  1.20E+4nMAssay Description:Displacement of [ 3H]-naloxone from rat brain membrane mu opioid receptor assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed