BDBM50064110 2-{2-[(S)-5-(2,4-Difluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoylamino}-propionic acid::CHEMBL147847

SMILES CC(C)C[C@H](NC(=O)[C@H](CC#Cc1ccc(F)cc1F)NCP(O)(O)=O)C(=O)N[C@@H](C)C(O)=O

InChI Key InChIKey=YMFLUOCULVUGIG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50064110   

TargetEndothelin-converting enzyme 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064110(CHEMBL147847 | 2-{2-[(S)-5-(2,4-Difluoro-phenyl)-2...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064110(CHEMBL147847 | 2-{2-[(S)-5-(2,4-Difluoro-phenyl)-2...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064110(CHEMBL147847 | 2-{2-[(S)-5-(2,4-Difluoro-phenyl)-2...)
Affinity DataIC50: 8nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064110(CHEMBL147847 | 2-{2-[(S)-5-(2,4-Difluoro-phenyl)-2...)
Affinity DataIC50: 5.80E+3nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed