BDBM50064096 CHEMBL40028::{[(S)-4-(2-Fluoro-phenyl)-1-(2H-tetrazol-5-yl)-but-3-ynylamino]-methyl}-phosphonic acid::{[4-(2-Fluoro-phenyl)-1-(1H-tetrazol-5-yl)-but-3-ynylamino]-methyl}-phosphonic acid

SMILES OP(O)(=O)CN[C@@H](CC#Cc1ccccc1F)c1nnn[nH]1

InChI Key InChIKey=ZVYGKCUEVQFXLW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50064096   

TargetNeprilysin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064096({[(S)-4-(2-Fluoro-phenyl)-1-(2H-tetrazol-5-yl)-but...)
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064096({[(S)-4-(2-Fluoro-phenyl)-1-(2H-tetrazol-5-yl)-but...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064096({[(S)-4-(2-Fluoro-phenyl)-1-(2H-tetrazol-5-yl)-but...)
Affinity DataIC50: 150nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064096({[(S)-4-(2-Fluoro-phenyl)-1-(2H-tetrazol-5-yl)-but...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed